Growth inhibition of head and neck carcinomas by D-allose.

Abstract

BACKGROUND:

An inhibitory effect of D-allose, a rare sugar, on several cancer cell lines has been reported. This study aimed to investigate the growth inhibition of head and neck squamous cell carcinoma cells by D-allose.

METHODS:

We treated 3 head and neck carcinoma cell lines with D-allose, D-fructose, D-psicose, and D-glucose. Cell growth assays as well as analyses of messenger RNA (mRNA) expression, cell cycle, apoptosis, and uptake of 14C-glucose were performed.

RESULTS:

D-allose had inhibitory effects on all 3 cell lines and tended to upregulate mRNA expression of glucose transporters, p21 and p53, and downregulate mRNA expression of cyclin A2, cyclin B1, and CDC2. We observed that D-allose tended to interfere with the intracellular uptake of D-glucose and induced apoptosis.

CONCLUSION:

Our results indicate that D-allose inhibits the growth of head and neck squamous cell carcinoma cells. D-allose has a considerable potential as a new anticancer agent in those patients.

• Authors: Tomoo Mitani, Hiroshi Hoshikawa, Terushige Mori, Tomohiro Hosokawa, Ikuko Tsukamoto, Fuminori Yamaguchi, Kazuyo Kamitori, Masaaki Tokuda, Nozomu Mori
• Journal: Head & neck (Head Neck) Vol. 31 Issue 8 Pg. 1049-55 (Aug 2009) ISSN: 1097-0347 [Electronic] United States
• PMID: 19340872 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2009 Wiley Periodicals, Inc.

Chemical References

• RNA, Messenger
• allose
• Glucose

Topics

• Apoptosis (drug effects)
• Carcinoma, Squamous Cell (drug therapy, pathology)
• Cell Cycle (drug effects, physiology)
• Cell Growth Processes (drug effects)
• Cell Line, Tumor (drug effects)
• Cell Proliferation (drug effects)
• Dose-Response Relationship, Drug
• Glucose (metabolism, pharmacology)
• Head and Neck Neoplasms (drug therapy, pathology)
• Humans
• In Situ Nick-End Labeling
• Mouth Neoplasms (drug therapy, pathology)
• Probability
• RNA, Messenger (analysis)
• Sensitivity and Specificity