Abstract | BACKGROUND:
Asthma is a major health problem worldwide, and the morbidity and mortality caused by asthma are on the rise. Corticosteroid therapies for asthma treatment frequently induce many side effects. Therefore, the development of new medicines that have both high efficacy and fewer side effects has been a scientific challenge. Here we tested the effect of ginsan, a polysaccharide derived from Panax ginseng, against allergic reaction in an ovalbumin (OVA)-induced murine asthmatic model in comparison with dexamethasone, and investigated its underlying mechanism. METHODS: RESULTS: CONCLUSION:
Ginsan has anti-asthmatic effects, which seem to be partially mediated by enhancing the synthesis of COX gene products.
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Authors | You-Jin Lim, Hee-Sam Na, Yeon-Sook Yun, Inseon S Choi, Jong-Suk Oh, Joon-Haeng Rhee, Bok-Hee Cho, Hyun-Chul Lee |
Journal | International archives of allergy and immunology
(Int Arch Allergy Immunol)
Vol. 150
Issue 1
Pg. 32-42
( 2009)
ISSN: 1423-0097 [Electronic] Switzerland |
PMID | 19339800
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2009 S. Karger AG, Basel. |
Chemical References |
- Allergens
- Anti-Inflammatory Agents
- Cytokines
- Plant Extracts
- Polysaccharides
- ginsan
- Immunoglobulin E
- Dexamethasone
- Ovalbumin
- Prostaglandin-Endoperoxide Synthases
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Topics |
- Allergens
(immunology, toxicity)
- Animals
- Anti-Inflammatory Agents
(therapeutic use)
- Asthma
(drug therapy, immunology)
- Blotting, Western
- Bronchoalveolar Lavage Fluid
(chemistry, cytology, immunology)
- Cytokines
(drug effects, metabolism)
- Dexamethasone
(therapeutic use)
- Disease Models, Animal
- Female
- Gene Expression
(drug effects, immunology)
- Immunoglobulin E
(blood)
- Mice
- Mice, Inbred BALB C
- Ovalbumin
(immunology, toxicity)
- Panax
(chemistry)
- Phytotherapy
(methods)
- Plant Extracts
(therapeutic use)
- Polysaccharides
(therapeutic use)
- Prostaglandin-Endoperoxide Synthases
(drug effects)
- Respiratory Hypersensitivity
(drug therapy, immunology)
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