KHSV(-) EBV(-) post-transplant effusion lymphoma with plasmablastic features: variant of primary effusion lymphoma?

Abstract

Primary effusion lymphoma (PEL) is a rare type of B-cell non-Hodgkin lymphoma (NHL), which predominantly occurs in HIV-infected individuals, and is pathogenetically linked with Kaposi sarcoma (KS)-associated herpes virus/human herpes virus-8 (KSHV/HHV-8) infection with or without evidence of Epstein-Barr virus (EBV) co-infection. Although uncommon, PELs have been reported in immunocompetent patients and recipients of solid organ allografts. Rare cases of KSHV(-) EBV(+) post-transplant effusion lymphomas resembling PEL have also been described, as have KSHV(-) EBV(-) effusion lymphomas, the latter including those arising in individuals with chronic liver disease. We report a unique KSHV(-) EBV(-) post-transplant effusion lymphoma associated with serum paraproteins, occurring in an HIV(-) individual, which had cytologic features and phenotype similar to PEL, and displayed a complex karyotype including isochromosome 12p and translocation t(8;22), resulting in rearrangement of c-MYC.

• Authors: Jennifer S Lambe, Darryl A Oble, Subhadra V Nandula, Deborah W Sevilla, Adriana I Colovai, Mahesh Mansukhani, Ajai Chari, Vundavalli V Murty, Bachir Alobeid, Govind Bhagat
• Journal: Hematological oncology (Hematol Oncol) Vol. 27 Issue 4 Pg. 203-10 (Dec 2009) ISSN: 1099-1069 [Electronic] England
• PMID: 19337983 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright (c) 2009 John Wiley & Sons, Ltd.

Topics

• Epstein-Barr Virus Infections (genetics, pathology)
• Herpesvirus 4, Human (isolation & purification)
• Herpesvirus 8, Human (isolation & purification)
• Humans
• Immunophenotyping
• Liver Transplantation
• Lymphoma, Primary Effusion (genetics, pathology, virology)
• Male
• Middle Aged
• Plasma Cells (pathology)
• Sarcoma, Kaposi (genetics, pathology, virology)