Abstract | OBJECTIVE: To evaluate the predictive value of stimulation day six serum estradiol (E2) for the probability of embryo cryopreservation after fresh embryo transfer in intracytoplasmic sperm injection (ICSI) cycles. SUBJECTS AND METHODS: SETTING: Alexandria IVF/ICSI center. MAIN OUTCOME MEASURES: Primary outcome measures are stimulation day-six serum E2, and rate of embryo cryopreservation, after transfer of three good-quality embryos. Secondary outcome measures are pregnancy rate per fresh embryo transfer, and other intermediate variables of the ICSI cycle. RESULTS: Patients were stratified into three groups according to day-six serum E2 levels: Group I with values <400 pg/mL; Group II, between 400 and 900; and Group III with values >900. The mean number of oocytes retrieved was 6.3, 8.9, and 12.4; the mean number of obtained embryos was 3.3, 4.8, and 6.7; and pregnancy rates were 18.1, 36.2, and 44.7% in the three groups, respectively. Rate of embryo cryopreservation, after transfer of three good-quality embryos was 70.7% in Group III, and 26.5% in Group I. (P = 0.01). The negative predictive value of day-six E2 <400 pg/mL for freezing was 83% while day-six serum E2 >900 pg/mL has a sensitivity of 55%, specificity of 72% and positive predictive value of 50% for embryo freezing. CONCLUSION: Higher stimulation day-six estradiol was associated with a higher probability of cryopreservation, and a higher pregnancy rate.
|
Authors | Hassan A El Maghraby, Mohamed Mahdi, Mervat Sheikh El Arab, Mohamed Mabrouk, Tullio Ghi, Antonio Farina |
Journal | The journal of obstetrics and gynaecology research
(J Obstet Gynaecol Res)
Vol. 35
Issue 2
Pg. 326-9
(Apr 2009)
ISSN: 1341-8076 [Print] Australia |
PMID | 19335799
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Adult
- Cryopreservation
- Estradiol
(blood)
- Female
- Fertilization in Vitro
- Humans
- Probability
- Sperm Injections, Intracytoplasmic
|