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Tumor necrosis factor-alpha levels after surgical anti-infective mechanical therapy for peri-implantitis: a 12-month follow-up.

AbstractBACKGROUND:
The aim of the present case series was to evaluate the effects of a surgical anti-infective mechanical therapy for peri-implantitis on clinical parameters and tumor necrosis factor-alpha (TNF-alpha) levels at 12 months post-therapy.
METHODS:
Ten patients with peri-implantitis were treated with open surgical debridement, abrasive sodium carbonate air-powder, and resin curets. Clinical parameters were recorded before and 3 and 12 months after therapy. At these time points, the total amounts of TNF-alpha in the peri-implant crevicular fluid were measured by enzyme-linked immunosorbent assay.
RESULTS:
At 3 and 12 months, the anti-infective therapy resulted in significant improvements in all clinical parameters (P <0.05). Moreover, the total amount of TNF-alpha was significantly reduced at 3 and 12 months after therapy compared to baseline (P <0.05), paralleling the changes in mean probing depth and bleeding on probing.
CONCLUSION:
The anti-infective mechanical therapy reduced the crevicular levels of TNF-alpha in sites affected by peri-implantitis over a period of 12 months, and this phenomenon was associated with improvements in clinical parameters.
AuthorsAdriana Cutrim de Mendonça, Vanessa Renata Santos, João Batista César-Neto, Poliana Mendes Duarte
JournalJournal of periodontology (J Periodontol) Vol. 80 Issue 4 Pg. 693-9 (Apr 2009) ISSN: 0022-3492 [Print] United States
PMID19335091 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Infective Agents, Local
  • Dental Implants
  • Mouthwashes
  • Tumor Necrosis Factor-alpha
  • chlorhexidine gluconate
  • Chlorhexidine
Topics
  • Aged
  • Anti-Infective Agents, Local (therapeutic use)
  • Chlorhexidine (analogs & derivatives, therapeutic use)
  • Debridement
  • Dental Implants (adverse effects)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Gingival Crevicular Fluid (chemistry)
  • Humans
  • Male
  • Middle Aged
  • Mouthwashes (therapeutic use)
  • Periodontal Index
  • Periodontitis (drug therapy, etiology, surgery)
  • Tumor Necrosis Factor-alpha (analysis, metabolism)

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