Safety and usefulness of intravenous iron sucrose in the management of preoperative anemia in patients with menorrhagia: a phase IV, open-label, prospective, randomized study.

Abstract

BACKGROUND:

The aim of this study was to compare the efficacy, safety and achievement of the target hemoglobin level (Hb >or=10 g/dl) in patients with preoperative anemia due to menorrhagia who received intravenous iron sucrose compared with oral iron protein succinylate for anemia management.

METHODS:

Seventy-six patients with Hb levels <9.0 g/dl who were scheduled to undergo surgical treatment were randomized to receive either intravenous iron sucrose (based on the calculated total iron deficit divided into 2 ampoule infusions intravenously 3 times a week, beginning 3 weeks before surgery) or oral iron (80 mg/day of oral iron protein succinylate daily).

RESULTS:

The intravenous iron group had higher increases in Hb (3.0 vs. 0.8 g/dl; p < 0.0001) and ferritin levels (170.1 vs. 4.1 microg/l; p < 0.0001) than the oral iron group. Achieving the target Hb was also higher in the intravenous iron group than in the oral iron group (76.7 vs. 11.5%; p < 0.0001). There were tolerable adverse events in both groups.

CONCLUSION:

Preoperative intravenous iron sucrose administration is more effective than oral iron and is as safe as oral iron therapy in the correction of preoperative anemia due to menorrhagia.

• Authors: Yun Hwan Kim, Hyun Hoon Chung, Soon-Beom Kang, Seung Cheol Kim, Young Tae Kim
• Journal: Acta haematologica (Acta Haematol) Vol. 121 Issue 1 Pg. 37-41 ( 2009) ISSN: 1421-9662 [Electronic] Switzerland
• PMID: 19332985 (Publication Type: Clinical Trial, Phase IV, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
• Copyright: (c) 2009 S. Karger AG, Basel.

Chemical References

• Ferric Compounds
• Hematinics
• Hemoglobins
• Ferritins
• Ferric Oxide, Saccharated
• Glucaric Acid

Topics

• Administration, Oral
• Adult
• Anemia (blood, therapy)
• Female
• Ferric Compounds (administration & dosage)
• Ferric Oxide, Saccharated
• Ferritins (blood)
• Glucaric Acid
• Hematinics (administration & dosage)
• Hemoglobins (analysis)
• Humans
• Infusions, Intravenous
• Menorrhagia (blood, therapy)
• Middle Aged
• Preoperative Care
• Prospective Studies