Abstract | BACKGROUND: METHODS: MEDLINE/CENTRAL/EMBASE database were searched from 1966 to August 2008 for randomized controlled trials of long-acting CCBs in patients with coronary artery disease with follow-up for at least 1 year. We extracted from the studies the baseline characteristics and 6 outcomes: all-cause mortality, cardiovascular mortality, nonfatal myocardial infarction, stroke, angina pectoris, and heart failure. RESULTS: Of the 100 randomized controlled trials of CCBs in patients with coronary artery disease, 15 studies evaluating 47,694 patients fulfilled our inclusion criteria. When compared with the comparison group (including placebo), CCBs were not associated with an increased risk of all-cause mortality (relative risk [RR] 0.99; 95% confidence interval [CI], 0.94-1.05), cardiovascular mortality (RR 1.03; 95% CI, 0.95-1.11), nonfatal myocardial infarction (RR 0.96; 95% CI, 0.87-1.06), or heart failure (RR 0.86; 95% CI, 0.71-1.05), and with a 21% reduction in the risk of stroke (95% CI, 0.70-0.89) and 18% reduction in the risk of angina pectoris (95% CI, 0.72-0.94). When compared with placebo, CCBs resulted in a 28% reduction in the risk of heart failure (95% CI, 0.73-0.92). The results were similar for both dihydropyridines and nondihydropyridine CCBs. CONCLUSIONS:
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Authors | Sripal Bangalore, Sanobar Parkar, Franz H Messerli |
Journal | The American journal of medicine
(Am J Med)
Vol. 122
Issue 4
Pg. 356-65
(Apr 2009)
ISSN: 1555-7162 [Electronic] United States |
PMID | 19332231
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
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Topics |
- Aged
- Calcium Channel Blockers
(adverse effects, pharmacokinetics, therapeutic use)
- Coronary Artery Disease
(drug therapy, metabolism)
- Female
- Humans
- Male
- Middle Aged
- Randomized Controlled Trials as Topic
- Risk Factors
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