Zafirlukast (Accolate): A new treatment for capsular contracture.

Abstract

BACKGROUND:

Capsular contracture after breast augmentation or reconstructive breast surgery is a difficult problem. Previous studies have suggested that alteration of the inflammatory response could have a role in reducing the incidence of capsular contracture.

OBJECTIVE:

We report a series of patients with Baker class III or IV capsular contracture who underwent treatment with zafirlukast.

METHODS:

Patients received a regimen of zafirlukast 20 mg by mouth 2 times daily for 3 months.

RESULTS:

In many cases, dramatic softening of the breast capsule was evident after 1 to 3 months of treatment.

CONCLUSIONS:

Zafirlukast appears to effectively soften early capsular contracture and may prevent the formation of capsular contracture in those patients at risk. (Aesthetic Surg J 2002;22:329-336.).

• Authors: S Larry Schlesinger, Richard Ellenbogen, Michael N Desvigne, Steven Svehlak, Robert Heck
• Journal: Aesthetic surgery journal (Aesthet Surg J) Vol. 22 Issue 4 Pg. 329-36 (Jul 2002) ISSN: 1527-330X [Electronic] England
• PMID: 19331987 (Publication Type: Journal Article)