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Erdosteine: its relevance in COPD treatment.

AbstractBACKGROUND:
Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by airflow limitation, which is largely irreversible; the oxidant/antioxidant imbalance is important in the pathogenesis of this condition.
OBJECTIVE:
To show that administration of erdosteine, a mucolytic agent with a prevalent antioxidant activity, could play a beneficial role in COPD.
METHODS:
To review the experimental and clinical trials on erdosteine in COPD and chronic bronchitis.
RESULTS:
Erdosteine is a thiol agent with a multifactorial mechanism of action, namely: mucolytic, antibacterial, antioxidant and anti-inflammatory activity. In the acute exacerbation of chronic bronchitis/COPD, addition of erdosteine 300 mg twice a day for 7 - 10 days to standard treatment improves the symptoms and reduces the time of disease. In clinically stable COPD, long-term treatment is associated with a reduction in acute exacerbation and hospitalization rate and a significant improvement of quality of life. Erdosteine could be most beneficial in patients who have repeated, prolonged or severe exacerbations of COPD.
AuthorsMaurizio Moretti
JournalExpert opinion on drug metabolism & toxicology (Expert Opin Drug Metab Toxicol) Vol. 5 Issue 3 Pg. 333-43 (Mar 2009) ISSN: 1744-7607 [Electronic] England
PMID19331595 (Publication Type: Journal Article, Review)
Chemical References
  • Antioxidants
  • Expectorants
  • Thioglycolates
  • Thiophenes
  • erdosteine
Topics
  • Animals
  • Antioxidants (adverse effects, pharmacology, therapeutic use)
  • Bronchitis (drug therapy)
  • Clinical Trials as Topic
  • Expectorants (adverse effects, pharmacology, therapeutic use)
  • Humans
  • Pulmonary Disease, Chronic Obstructive (drug therapy, physiopathology)
  • Quality of Life
  • Severity of Illness Index
  • Thioglycolates (adverse effects, pharmacology, therapeutic use)
  • Thiophenes (adverse effects, pharmacology, therapeutic use)

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