Abstract | BACKGROUND/AIMS: METHODS: Ten gallbladder adenocarcinoma, 8 distal bile duct carcinomas (distal cholangiocarcinoma), 8 Klatskin tumors, 8 intrahepatic cholangiocarcinomas and 10 ampullary carcinomas were included in the study. The immunohistochemical expression of MMP-2, MMP-9 and MMP-14 was detected in the nontumoral, metaplastic, dysplastic and tumoral epithelia. The tumor differentiation, angiolymphatic and perineural invasion of the tumor, and presence of lymph node and distant metastasis were determined. Survey of the patients was noted from the patient follow-up data. RESULTS: The nontumoral epithelia of the gallbladder, intrahepatic ducts, and Klatskin tumor did not express MMP-2. MMP-2 expression was detected in the distal part of the biliary ducts, in 75% (6/18) of cases and in the nontumoral epithelia of the ampullary region in 50% (5/10) of cases. The metaplastic and dysplastic epithelia were positively stained in all of the gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary tumors. In the intrahepatic cholangiocarcinoma, the hepatocytes were positively stained but the infiltrative tumors were spared. Klatskin tumors were also not stained with MMP-2. The gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary carcinomas expressed MMP-2 in 30%, 37% and 40% of the cases, respectively. MMP-9 and MMP-14 were expressed in normal, metaplastic, and dysplastic epithelium and tumoral cells in all of the cases of the groups. Expressions of MMPs were higher in subjects with neural invasion, but there was no correlation between MMP expression and tumor differentiation or angiolymphatic invasion. CONCLUSIONS:
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Authors | Hale Kirimlioğlu, Ilknur Türkmen, Nuray Başsüllü, Abuzer Dirican, Neşe Karadağ, Vedat Kirimlioğlu |
Journal | The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
(Turk J Gastroenterol)
Vol. 20
Issue 1
Pg. 41-7
(Mar 2009)
ISSN: 2148-5607 [Electronic] Turkey |
PMID | 19330734
(Publication Type: Journal Article)
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Chemical References |
- Matrix Metalloproteinases
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
- Matrix Metalloproteinase 14
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Topics |
- Adenocarcinoma
(metabolism, pathology)
- Ampulla of Vater
(enzymology, pathology)
- Bile Duct Neoplasms
(metabolism, pathology)
- Bile Ducts, Intrahepatic
(enzymology, pathology)
- Cholangiocarcinoma
(metabolism, pathology)
- Disease Progression
- Gallbladder Neoplasms
(metabolism, pathology)
- Hepatic Duct, Common
(enzymology, pathology)
- Humans
- Immunohistochemistry
- Klatskin Tumor
(metabolism, pathology)
- Matrix Metalloproteinase 14
(metabolism)
- Matrix Metalloproteinase 2
(metabolism)
- Matrix Metalloproteinase 9
(metabolism)
- Matrix Metalloproteinases
(metabolism)
- Neoplasm Invasiveness
- Prognosis
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