Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese.

Abstract

The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.

• Authors: E K Tan, C S Lu, R Peng, Y Y Teo, Y H Wu-Chou, R S Chen, Y H Weng, C M Chen, H C Fung, L C Tan, Z J Zhang, X K An, G J Lee-Chen, M C Lee, S Fook-Chong, J M Burgunder, R M Wu, Y R Wu
• Journal: Neurobiology of aging (Neurobiol Aging) Vol. 31 Issue 12 Pg. 2194-6 (Dec 2010) ISSN: 1558-1497 [Electronic] United States
• PMID: 19329225 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2008 Elsevier Inc. All rights reserved.

Chemical References

• UCHL1 protein, human
• Ubiquitin Thiolesterase

Topics

• Adolescent
• Adult
• Age of Onset
• Aged
• Aged, 80 and over
• Asian People (ethnology, genetics)
• Female
• Genetic Association Studies
• Genetic Variation (genetics)
• Humans
• Male
• Middle Aged
• Parkinson Disease (enzymology, epidemiology, genetics)
• Singapore (epidemiology, ethnology)
• Taiwan (epidemiology, ethnology)
• Ubiquitin Thiolesterase (genetics)
• Ubiquitination (genetics)
• Young Adult