Abstract | BACKGROUND: Adults and children with recurrent malignant central nervous system (CNS) tumors have a poor prognosis despite high dose chemotherapy with a conventional stem cell rescue regimen. In this study we evaluated the results of low dose, continuous infusion etoposide over 21 days added to a conventional high-dose regimen of carboplatin and thiotepa in eight patients with relapsed pediatric CNS tumors. PROCEDURE: Patients with high risk CNS tumors were treated with etoposide 25 mg/m(2)/day by continuous intravenous (IV) infusion from day -22 to day -2, carboplatin 667 mg/m(2)/dose IV (or area under the curve = 9 mg/ml/min according to the Calvert formula on days -8, -7, and -6, and thiotepa 300 mg/m(2)/dose IV on days -5, -4, and -3, followed by autologous hematopoietic stem cell rescue on day 0. RESULTS: Eight adults and children, with a mean age of 12.9 years (age range 5.6-27.8 years), with relapsed primary CNS tumors (metastatic medulloblastoma (7), germinoma (1)), were enrolled. The mean survival post-transplant was 4.8+ years, (range 8-160+ months). The 2- and 5-year overall survival rates were 75% and 50% respectively. None of the survivors required additional salvage irradiation. CONCLUSION: The strategy of low dose chronic exposure to a topoisomerase inhibitor along with ablative carboplatin and thiotepa with stem cell rescue showed promising survival outcomes in these relapsed patients. This treatment strategy deserves further evaluation in a larger group of high-risk or relapsed primary CNS tumors.
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Authors | Howard Grodman, Lawrence Wolfe, Cynthia Kretschmar |
Journal | Pediatric blood & cancer
(Pediatr Blood Cancer)
Vol. 53
Issue 1
Pg. 33-6
(Jul 2009)
ISSN: 1545-5017 [Electronic] United States |
PMID | 19326417
(Publication Type: Journal Article)
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Copyright | Copyright 2009 Wiley-Liss, Inc. |
Chemical References |
- Etoposide
- Thiotepa
- Carboplatin
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Topics |
- Adolescent
- Adult
- Anemia
(chemically induced, therapy)
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Carboplatin
(administration & dosage)
- Central Nervous System Neoplasms
(mortality, therapy)
- Child
- Child, Preschool
- Etoposide
(administration & dosage)
- Female
- Germinoma
(mortality, therapy)
- Hematologic Diseases
(chemically induced, therapy)
- Hematopoietic Stem Cell Transplantation
- Humans
- Infusions, Intravenous
- Male
- Neoplasm Recurrence, Local
(mortality, therapy)
- Survival Rate
- Thiotepa
(administration & dosage)
- Treatment Outcome
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