The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.

Abstract

Selective trafficking of membrane proteins to lysosomes for destruction is required for proper cell signalling and metabolism. Ubiquitylation aids this process by specifying which proteins should be transported to the lysosome lumen by the multivesicular endosome pathway. The endosomal sorting complex required for transport (ESCRT) machinery sorts cargo labelled with ubiquitin into invaginations of endosome membranes. Then, through a highly conserved mechanism also used in cytokinesis and viral budding, it mediates the breaking off of the cargo-containing intraluminal vesicles from the perimeter membrane. The involvement of the ESCRT machinery in suppressing diseases such as cancer, neurodegeneration and infections underscores its importance to the cell.

• Authors: Camilla Raiborg, Harald Stenmark
• Journal: Nature (Nature) Vol. 458 Issue 7237 Pg. 445-52 (Mar 26 2009) ISSN: 1476-4687 [Electronic] England
• PMID: 19325624 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Membrane Proteins
• Vesicular Transport Proteins

Topics

• Animals
• Autophagy
• Cytokinesis
• Endosomes (metabolism)
• Humans
• Membrane Proteins (metabolism)
• Protein Transport
• Ubiquitination
• Vesicular Transport Proteins (metabolism)
• Virus Assembly