Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance.

Abstract

OBJECTIVE:

Coffee consumption has been associated with lower risk of type 2 diabetes. We evaluated the acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance.

RESEARCH DESIGN AND METHODS:

We conducted a randomized crossover trial of the effects of 12 g decaffeinated coffee, 1 g chlorogenic acid, 500 mg trigonelline, and placebo (1 g mannitol) on glucose and insulin concentrations during a 2-h oral glucose tolerance test (OGTT) in 15 overweight men.

RESULTS:

Chlorogenic acid and trigonelline ingestion significantly reduced glucose (-0.7 mmol/l, P = 0.007, and -0.5 mmol/l, P = 0.024, respectively) and insulin (-73 pmol/l, P = 0.038, and -117 pmol/l, P = 0.007) concentrations 15 min following an OGTT compared with placebo. None of the treatments affected insulin or glucose area under the curve values during the OGTT compared with placebo.

CONCLUSIONS:

Chlorogenic acid and trigonelline reduced early glucose and insulin responses during an OGTT.

• Authors: Aimée E van Dijk, Margreet R Olthof, Joke C Meeuse, Elin Seebus, Rob J Heine, Rob M van Dam
• Journal: Diabetes care (Diabetes Care) Vol. 32 Issue 6 Pg. 1023-5 (Jun 2009) ISSN: 1935-5548 [Electronic] United States
• PMID: 19324944 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Blood Glucose
• Coffee
• Insulin
• Placebos
• Chlorogenic Acid
• Caffeine
• trigonelline
• Mannitol

Topics

• Alkaloids (pharmacology)
• Blood Glucose (drug effects, metabolism)
• Caffeine
• Chlorogenic Acid (pharmacology)
• Coffee
• Cross-Over Studies
• Glucose Tolerance Test
• Humans
• Insulin (blood)
• Male
• Mannitol (pharmacology)
• Overweight (blood, physiopathology)
• Placebos