Polyneuritis cranialis presenting with anti-GQ1b IgG antibody.

Abstract

A 52-year-old man developed diplopia, a nasal voice, dysphagia, hoarseness and slight bilateral facial palsies. There was no ataxia, areflexia, limb weakness or sensory involvement. Serum anti-GQ1b IgG antibody was present. Treatment with intravenous immunoglobulin started, and the patient responded with a rapid resolution of symptoms. The diagnosis is consistent with polyneuritis cranialis which is considered to be a Guillain-Barre syndrome variant, a forme fruste, but very rare. The diagnosis can be difficult and a thorough investigation is required. Electrophysiological examination, laboratory evaluations, imaging and cerebrospinal fluid examination are often required in the investigations. Cranial neuropathy can be the presentation of many disorders. Determination of anti-ganglioside antibodies as anti-GQ1b is valuable to the diagnosis, and shows the association with the Guillain-Barre syndrome.

• Authors: Bengt Edvardsson, Staffan Persson
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 281 Issue 1-2 Pg. 125-6 (Jun 15 2009) ISSN: 1878-5883 [Electronic] Netherlands
• PMID: 19324375 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Gangliosides
• Immunoglobulin G
• GQ1b ganglioside

Topics

• Autoantibodies (blood)
• Cranial Nerve Diseases (diagnosis, immunology)
• Diagnosis, Differential
• Gangliosides (immunology)
• Guillain-Barre Syndrome (blood, diagnosis, immunology)
• Humans
• Immunoglobulin G (blood)
• Male
• Middle Aged
• Neuritis (diagnosis, immunology)