Abstract | BACKGROUND: The purpose of this study was to examine the role of erythropoietin in retinal ischemic preconditioning (IPC). METHODS: RESULTS: CONCLUSIONS: These results indicate that EPO-R upregulation is a critical component of the functional, histologic, and antiapoptotic protective effect of IPC on ischemia in the retina and that several downstream effectors may be involved in the neuroprotective actions of erythropoietin.
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Authors | John C Dreixler, Sarah Hagevik, Jonathan W Hemmert, Afzhal R Shaikh, Daniel M Rosenbaum, Steven Roth |
Journal | Anesthesiology
(Anesthesiology)
Vol. 110
Issue 4
Pg. 774-80
(Apr 2009)
ISSN: 1528-1175 [Electronic] United States |
PMID | 19322943
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- HSP27 Heat-Shock Proteins
- Receptors, Erythropoietin
- Erythropoietin
- Proto-Oncogene Proteins c-akt
- Extracellular Signal-Regulated MAP Kinases
- DNA Nucleotidylexotransferase
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Topics |
- Animals
- Apoptosis
- Blotting, Western
- DNA Nucleotidylexotransferase
- Electroretinography
- Erythropoietin
(analysis, pharmacology, physiology)
- Extracellular Signal-Regulated MAP Kinases
(metabolism)
- Fluorescent Antibody Technique, Indirect
- HSP27 Heat-Shock Proteins
- In Situ Nick-End Labeling
- Ischemic Preconditioning
- Neurons
(cytology, drug effects)
- Proto-Oncogene Proteins c-akt
- Rats
- Rats, Sprague-Dawley
- Receptors, Erythropoietin
(analysis)
- Reperfusion Injury
(enzymology, prevention & control)
- Retina
(cytology, drug effects)
- Retinal Vessels
- Solubility
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