Acute lymphoblastic leukemia secondary to chemoradiotherapy for perivascular epithelioid cell tumor of uterus.

Abstract

Acute lymphoblastic leukemia (ALL), a primary hematologic malignancy that is especially common in childhood, occurs relatively rarely as a secondary malignant neoplasm. Available data indicate that ALL often follows chemoradiotherapy for soft tissue sarcoma. Perivascular epithelioid tumor (PEComa), a primitive mesenchymal tissue origin, can be classified as a soft tissue sarcoma. An 11-year-old girl was diagnosed with ALL secondary to chemoradiotherapy (vincristine, ifosfamide, and anthracycline) and radiotherapy comprising 45 Gy to the whole pelvis for PEComa. ALL, FAB L2, and immunophenotypically pro-B developed 16 months after the final chemotherapy treatment. Moreover, a cytogenetic study of lymphoblasts showed t(1;11)(p32;q23). Herein, the authors report a case of secondary ALL that might be related to a previously used intercalating DNA topoisomerase II inhibitor (anthracycline) for a very rare sarcoma, PEComa.

• Authors: In-sang Jeon, Dae Yong Yi
• Journal: Pediatric hematology and oncology (Pediatr Hematol Oncol) Vol. 26 Issue 2 Pg. 85-8 (Mar 2009) ISSN: 1521-0669 [Electronic] England
• PMID: 19322738 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anthracyclines
• Topoisomerase II Inhibitors

Topics

• Anthracyclines (adverse effects)
• Child
• Cytogenetic Analysis
• Female
• Humans
• Neoplasms, Second Primary (etiology, genetics)
• Perivascular Epithelioid Cell Neoplasms (complications, drug therapy, radiotherapy)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (etiology, genetics)
• Precursor Cells, B-Lymphoid (pathology)
• Topoisomerase II Inhibitors
• Translocation, Genetic
• Uterine Neoplasms (complications, drug therapy, radiotherapy)