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Improved survival in patients with breast rhabdoid tumors with multi-agent adjuvant chemotherapy combined with irradiation.

AbstractPURPOSE:
Malignant rhabdoid tumors (MRT) have poor prognoses. Breast MRT is extremely rare; only three cases have been documented, with a mean prognosis of 7 months. Multi-agent chemotherapy with mastectomy and irradiation, as used in this case, may extend survival in breast MRT.
PATIENT AND METHODS:
A 68-year-old woman who underwent a standard mastectomy was diagnosed with breast MRT. Postoperatively she received six cycles of cyclophosphamide/methotrexate/5-fluorouracil followed by oral administration of doxifluridine and anastrozole, after which no metastasis was detected. About 8 months postoperative, magnetic resonance imaging revealed cervical bone metastasis, and local irradiation and nine doses of "basic chemotherapy" consisting of biweekly paclitaxel and anastrozole were administered. About 4 months later, multiple lung metastases were revealed, and four doses of "basic chemotherapy" with added pirarubicin hydrochloride were administered. Four months after that, multiple large liver metastases were discovered, and five doses of "basic chemotherapy" with added carboplatin were administered.
RESULTS:
The 19-month survival period of our case was almost three times that of reported breast MRT patients.
CONCLUSION:
Multi-agent chemotherapy combined with irradiation may be associated with the relatively long survival of the present case.
AuthorsYoshitaka Furuya, Hironobu Yanagie, Takashi Wakahara, Yoshiya Mishina, Harutoshi Akimoto, Le Minh Quang, Kenzo Hiroshima, Hiroshi Yasuhara
JournalCancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 64 Issue 3 Pg. 623-7 (Aug 2009) ISSN: 1432-0843 [Electronic] Germany
PMID19322564 (Publication Type: Case Reports, Journal Article)
Topics
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Breast Neoplasms (physiopathology, therapy)
  • Chemotherapy, Adjuvant (methods)
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Mastectomy
  • Neoplasm Metastasis
  • Rhabdoid Tumor (physiopathology, therapy)
  • Survival Rate

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