Sincalide is a rapid-acting, synthetic analog of
cholecystokinin for intravenous use in postevacuation cholecystography. Serious reactions to
sincalide have not been reported. The
intravenous administration of
sincalide causes a prompt contraction of the gallbladder as compared to the stimulus of a fatty meal which causes progressive contraction that becomes maximal in about 40 minutes. The use of
Kinevac to accelerate the transit time through the small bowel decreases the time and extent of radiation associated with fluoroscopy and length of the x-ray examination of the intestinal tract. Duodenal aspiration obtained after the administration of
Kinevac provides a sample of concentrated bile for analysis of
cholesterol,
bile salts,
phospholipids and crystals. When used in conjunction with
secretin to stimulate pancreatic secretion, an aspirate is readily obtained for analysis of
enzyme activity, composition and cytology. As the development of endoscopic manometry affords a modality to measure and record sphincter of Oddi pressures, the paradoxical responses noted to the
intravenous administration of CCK during manometric evaluation supports the diagnostic value of
Kinevac used as a provocative agent in the evaluation of
biliary dyskinesia.