Abstract |
Calciphylaxis is a rare complication that occurs in 1% of patients with end-stage renal disease ( ESRD) each year. Extensive microvascular calcification and occlusion/ thrombosis lead to violaceous skin lesions, which progress to nonhealing ulcers with secondary infection, often leading to sepsis and death. The lower extremities are predominantly involved (roughly 90% of patients). Although most calciphylaxis patients have abnormalities of the calcium-phosphate axis or elevated levels of parathyroid hormone, these abnormalities do not appear to be fundamental to the pathophysiology of the disorder. We report on a case of histologically proven calciphylaxis in a 54-year-old woman with normal renal function and normal calcium-parathyroid homeostasis. She had a history of alcoholic cardiomyopathy, and was treated with warfarin anticoagulation. She has been successfully treated with antibiotics, i.v. biophosphonates and intensive local wound care. We recorded a complete wound healing in contrast to what is reported in other series.
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Authors | Amar Almafragi, Jo Vandorpe, Karl Dujardin |
Journal | Acta cardiologica
(Acta Cardiol)
Vol. 64
Issue 1
Pg. 91-3
(Feb 2009)
ISSN: 0001-5385 [Print] England |
PMID | 19317304
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Anticoagulants
- Diphosphonates
- Thienamycins
- Clindamycin
- Warfarin
- Vancomycin
- Meropenem
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Topics |
- Alcoholism
(complications)
- Anti-Bacterial Agents
(therapeutic use)
- Anticoagulants
(adverse effects)
- Calciphylaxis
(chemically induced, drug therapy, etiology, physiopathology)
- Clindamycin
(therapeutic use)
- Diphosphonates
(therapeutic use)
- Female
- Heart Diseases
(complications, etiology, physiopathology)
- Humans
- Kidney Failure, Chronic
(physiopathology)
- Meropenem
- Middle Aged
- Risk Factors
- Thienamycins
(therapeutic use)
- Vancomycin
(therapeutic use)
- Warfarin
(adverse effects)
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