Products of lipid peroxidation and changes in sulfhydryl compounds in pancreatic tissue of rats with caerulein-induced acute pancreatitis.

Acute edematous pancreatitis was induced in rats by iv infusion of caerulein (CR) in a supramaximal dose of 7.5 x 10(-6)g x kg-1 x hr-1 during 6 hr. The most important finding of our study was the marked decrease of protein and nonprotein thiol content in pancreatic tissue of rats with CR-induced acute pancreatitis (AP). Oxygen radicals as well as 4-hydroxyalkenals resulting from lipid peroxidation are believed to be at least partly responsible for this phenomenon. Covalent binding of excessive amounts of 4-hydroxyalkenals to pancreatic tissue protein sulfhydryl groups has been documented. Presented data suggest a serious disturbance of sulfhydryl compounds metabolism in pancreatic tissue of rats with CR-induced AP which may be of importance in the pathogenesis of the disease.
AuthorsA Dabrowski, A Gabryelewicz, M Chwiećko
JournalBiochemical medicine and metabolic biology (Biochem Med Metab Biol) Vol. 46 Issue 1 Pg. 10-6 (Aug 1991) ISSN: 0885-4505 [Print] UNITED STATES
PMID1931150 (Publication Type: Journal Article)
Chemical References
  • Free Radicals
  • Proteins
  • Sulfhydryl Compounds
  • Ceruletide
  • Acute Disease
  • Animals
  • Ceruletide
  • Free Radicals
  • Lipid Peroxidation
  • Male
  • Pancreas (metabolism)
  • Pancreatitis (chemically induced, metabolism)
  • Proteins (metabolism)
  • Rats
  • Rats, Inbred Strains
  • Sulfhydryl Compounds (metabolism)

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