Abstract |
Silicosis patients (SILs) possess not only respiratory disorders but also alterations in autoimmunity. To determine an early indicator of immunological disturbance in SILs, the role of serum-soluble interleukin (IL)-2 receptor (sIL-2R) was analyzed. Of ten SILs, immunological clinical parameters such as immunoglobulin (Ig) G, complements, the titer of autoantibodies including anti-nuclear antibodies (ANA), anti-Scl-70 antibody (Ab) and anti-centromere (CM) Ab, and experimental indicators such as serum-soluble Fas, serum IL-2, CD25+ cells in CD4+ or CD8+ fractions, and sIL-2R were divided from respiratory parameters such as percent vital capacity (%VC), percentage of forced expiratory volume in 1 second (FEV1.0%) and v25/Ht (liter/second/m(body height) by a correlation assay. Additionally, a stepwise regression test showed that sIL-2R was correlated with Ig G, ANA and anti-CM Ab. Furthermore, factor analysis revealed that sIL-2R contributed to the subpopulation of SILs with poorer immunological status in the absence of alterations in respiratory status. By defining healthy donors as 1, SILs as 2 and patients with systemic sclerosis as 3 for immunopathological progression status as metric variables, sIL2R and ANA showed a strong positive correlation. This suggests that sIL-2R is a good clinical indicator of immunological disturbance found in SILs without clinical manifestations of any disturbance in autoimmunity. Further analysis using a large-scale number of patients should be performed to confirm these findings.
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Authors | H Hayashi, M Maeda, S Murakami, N Kumagai, Y Chen, T Hatayama, M Katoh, N Miyahara, S Yamamoto, Y Yoshida, Y Nishimura, M Kusaka, W Fujimoto, T Otsuki |
Journal | International journal of immunopathology and pharmacology
(Int J Immunopathol Pharmacol)
2009 Jan-Mar
Vol. 22
Issue 1
Pg. 53-62
ISSN: 0394-6320 [Print] England |
PMID | 19309552
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Interleukin-2
- Receptors, Interleukin-2
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Topics |
- Adult
- Aged
- Biomarkers
- Blood Donors
- Female
- Forced Expiratory Volume
- Humans
- Interleukin-2
(blood)
- Male
- Middle Aged
- Receptors, Interleukin-2
(blood)
- Scleroderma, Systemic
(immunology)
- Silicosis
(immunology, physiopathology)
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