Abstract |
We investigated novel antibacterial and synergistic activities of isocryptomerin isolated from Selaginella tamariscina. Isocryptomerin showed potent antibacterial activity against Gram-positive and Gram-negative bacterial strains including clinical isolates of antibiotic-resistant species such as methicillin-resistant Staphylococcus aureus (MRSA). Additionally, we further investigated the synergistic activity of isocryptomerin with a conventional antibiotic against MRSA. The result indicated that isocryptomerin had considerable synergistic activity in combination with cefotaxime. In summary, the present study suggests that isocryptomerin may have potential as a novel therapeutic agent for treatment of infectious diseases by not only human pathogenic bacteria but also multidrug-resistant bacteria.
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Authors | Juneyoung Lee, Yunjung Choi, Eun-Rhan Woo, Dong Gun Lee |
Journal | Journal of microbiology and biotechnology
(J Microbiol Biotechnol)
Vol. 19
Issue 2
Pg. 204-7
(Feb 2009)
ISSN: 1017-7825 [Print] Korea (South) |
PMID | 19307771
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Flavones
- isocryptomerin
- Cefotaxime
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Topics |
- Anti-Bacterial Agents
(pharmacology)
- Cefotaxime
(pharmacology)
- Drug Synergism
- Flavones
(pharmacology)
- Methicillin-Resistant Staphylococcus aureus
(drug effects)
- Microbial Sensitivity Tests
- Molecular Structure
- Selaginellaceae
(chemistry)
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