Expression of the Breast Cancer Metastasis Suppressor 1 (BRMS1) maintains in vitro chemosensitivity of breast cancer cells.

Abstract	The Breast Cancer Metastasis Suppressor 1 (BRMS1) belongs to an expanding category of proteins called metastasis suppressors that demonstrate in vivo metastasis suppression while still allowing growth of the orthotopic tumor. Since BRMS1 decreases either the expression or function of multiple mediators implicated in resistance to chemotherapy (NF-kappaB, AKT, EGFR), we asked whether breast carcinoma cells expressing BRMS1 could be sensitized upon exposure to commonly used therapeutic agents that inhibit some of these same cellular mediators as BRMS1. In this report, we demonstrate that chemosensitivity of breast cancer cells is preserved in the presence of BRMS1. Further, BRMS1 does not change expression of AKT isoforms or PTEN, implicated in chemoresistance to common drug agents. Overall, our data with two different metastatic breast cancer cell lines indicates that BRMS1 expression status may not interfere with the response to commonly used chemotherapeutic agents in the management of solid tumors such as breast cancer. Since tumor protein expression analysis increasingly guides therapy decisions, our data may be of clinical benefit in disease management including profiling for BRMS1 expression before start of therapy.
Authors	Kedar S Vaidya, Jesus J Sanchez, Eun Lim Kim, Danny R Welch
Journal	Cancer letters (Cancer Lett) Vol. 281 Issue 1 Pg. 100-7 (Aug 18 2009) ISSN: 1872-7980 [Electronic] Ireland
PMID	19307053 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents BRMS1 protein, human Neoplasm Proteins Protein Isoforms Recombinant Fusion Proteins Repressor Proteins Vincristine Doxorubicin AKT1 protein, human Proto-Oncogene Proteins c-akt PTEN Phosphohydrolase PTEN protein, human Paclitaxel Fluorouracil
Topics	Adenocarcinoma (pathology) Antineoplastic Agents (pharmacology) Breast Neoplasms (pathology) Cell Division (drug effects) Cell Line, Tumor (drug effects, metabolism, pathology) Doxorubicin (pharmacology) Drug Resistance, Neoplasm (genetics, physiology) Female Fluorouracil (pharmacology) Gene Expression Regulation, Neoplastic (drug effects) Humans Neoplasm Proteins (biosynthesis, genetics, physiology) PTEN Phosphohydrolase (biosynthesis, genetics) Paclitaxel (pharmacology) Protein Isoforms (biosynthesis, genetics) Proto-Oncogene Proteins c-akt (biosynthesis, genetics) Recombinant Fusion Proteins (physiology) Repressor Proteins Tumor Stem Cell Assay Vincristine (pharmacology)

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