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The effect of 2-deoxy-D-glucose on Werner syndrome RecQ helicase gene.

Abstract
Caloric restriction (CR) is known to effectively elongate mammalian life-spans. The compound 2-deoxy-D-glucose (2DG), which is often used as an inhibitor of glucose utilization, is a mimetic agent of CR. In this study, we examined the changes of telomerase and Werner's syndrome RecQ (WRN) helicase after treatment with 2DG, because of the involvement of recQ helicase in the regulation of telomeres. Interestingly, 2DG treatment increased the expression of WRN protein in accordance with induction of its promoter activity and gene expression. Furthermore, the activation of telomerase was observed after 2DG treatment, whereas it resulted in the reduction of cell proliferation. These results suggest that 2DG could up-regulate telomere maintenance factors accompanied with suppression of proliferation.
AuthorsBei Zhou, Takashi Ikejima, Takeshi Watanabe, Keiko Iwakoshi, Yohei Idei, Sei-ichi Tanuma, Fumiaki Uchiumi
JournalFEBS letters (FEBS Lett) Vol. 583 Issue 8 Pg. 1331-6 (Apr 17 2009) ISSN: 1873-3468 [Electronic] England
PMID19306876 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DNA Primers
  • Deoxyglucose
  • Telomerase
  • RecQ Helicases
Topics
  • Base Sequence
  • Blotting, Western
  • Cell Line, Tumor
  • DNA Primers
  • Deoxyglucose (pharmacology)
  • Enzyme Activation
  • Humans
  • Polymerase Chain Reaction
  • Promoter Regions, Genetic
  • RecQ Helicases (genetics)
  • Telomerase (metabolism)
  • Werner Syndrome (enzymology)

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