Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man.

Abstract

An experimental evaluation of citrulline malate (Stimol, CAS 54940-97-5), an anti-fatigue compound, was undertaken in man and in the animal in order to study the pharmacological activity of the substance at hepatic and renal level. In man, the protocol involved a double-blind randomized, placebo-controlled cross-over technique. The study in the animal was blind and placebo-controlled with two randomized parallel groups. Results showed that citrulline malate stimulates hepatic ureogenesis and favorizes the renal reabsorption of bicarbonates. These metabolic actions had a protective effect against acidosis and ammonia poisoning and explain the anti-fatigue properties of citrulline malate in man.

• Authors: A Callis, B Magnan de Bornier, J J Serrano, H Bellet, R Saumade
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 41 Issue 6 Pg. 660-3 (Jun 1991) ISSN: 0004-4172 [Print] Germany
• PMID: 1930358 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Amino Acids
• Malates
• Citrulline
• Ammonia
• citrulline malate

Topics

• Acid-Base Equilibrium (drug effects)
• Adult
• Amino Acids (blood)
• Ammonia (blood)
• Animals
• Citrulline (analogs & derivatives, pharmacology)
• Double-Blind Method
• Female
• Humans
• Kidney (drug effects, metabolism)
• Liver (drug effects, metabolism)
• Malates (pharmacology)
• Male
• Rats
• Rats, Inbred Strains