4-Methoxycinnamaldehyde inhibited human respiratory syncytial virus in a human larynx carcinoma cell line.

Abstract

4-Methoxycinnamaldehyde, an active constituent of Agastache rugosa, was examined for its cytoprotective activity against RSV by XTT method in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde could effectively inhibit cytopathic effect of RSV (p<0.0001) with an estimated IC(50) of 0.055microg/ml and a selectivity index (SI) of 898.2. 4-Methoxycinnamaldehyde (0.03microg/ml) could inhibit viral entrance by interfering viral attachment (IC(50) of 0.06microg/ml; p<0.0001) and internalization (IC(50) of 0.01microg/ml; p<0.0001). 4-Methoxycinnamaldehyde significantly increased the basal production of IFN (p=0.0015), but not the virus-induced IFN production. Therefore, its cytoprotective activity against RSV was not mediated by interferon. In conclusion, 4-methoxycinnamaldehyde might be helpful to manage the disease induced by RSV infection.

• Authors: Kuo Chih Wang, Jung San Chang, Lien Chai Chiang, Chun Ching Lin
• Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology (Phytomedicine) Vol. 16 Issue 9 Pg. 882-6 (Sep 2009) ISSN: 1618-095X [Electronic] Germany
• PMID: 19303275 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 4-methoxycinnamaldehyde
• Plant Extracts
• Acrolein
• Interferons

Topics

• Acrolein (analogs & derivatives, pharmacology, therapeutic use)
• Agastache (chemistry)
• Cell Line, Tumor
• Humans
• Interferons (metabolism)
• Laryngeal Neoplasms
• Phytotherapy
• Plant Extracts (pharmacology, therapeutic use)
• Respiratory Syncytial Virus Infections (complications, drug therapy, virology)
• Respiratory Syncytial Virus, Human (drug effects)
• Virus Attachment (drug effects)
• Virus Internalization (drug effects)