Abstract | BACKGROUND & AIMS: METHODS: We transplanted F344 rat hepatocytes into syngeneic dipeptidyl peptidase IV-deficient F344 rats. Changes in cyclooxygenase pathways were analyzed, and specific pathways were blocked pharmacologically; the effects on cell engraftment and native liver cells were determined. RESULTS: CONCLUSIONS:
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Authors | Yuta Enami, Sriram Bandi, Sorabh Kapoor, Natan Krohn, Brigid Joseph, Sanjeev Gupta |
Journal | Gastroenterology
(Gastroenterology)
Vol. 136
Issue 7
Pg. 2356-64
(Jun 2009)
ISSN: 1528-0012 [Electronic] United States |
PMID | 19303017
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Pyrazoles
- RNA, Messenger
- Sulfonamides
- Naproxen
- Prostaglandin-Endoperoxide Synthases
- Celecoxib
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Topics |
- Analysis of Variance
- Animals
- Blotting, Western
- Celecoxib
- Cell Survival
(drug effects, physiology)
- Cells, Cultured
- Disease Models, Animal
- Female
- Graft Survival
- Hepatic Stellate Cells
(drug effects, physiology)
- Hepatocytes
(transplantation)
- Immunohistochemistry
- Kupffer Cells
(cytology)
- Male
- Naproxen
(pharmacology)
- Phagocytosis
(drug effects, physiology)
- Probability
- Prostaglandin-Endoperoxide Synthases
(drug effects, metabolism)
- Pyrazoles
(pharmacology)
- RNA, Messenger
(analysis)
- Random Allocation
- Rats
- Rats, Inbred F344
- Signal Transduction
(physiology)
- Sulfonamides
(pharmacology)
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