Magnetic field elicits hypotension mediated by platelet activating factor in rats injected with iron beads.

Abstract

Rats injected intravenously with iron beads (avg. diameter 3.4 microns; 1 g/kg body weight) were exposed to static or time-varying magnetic fields (400 gauss) for 5 min, which elicited a marked and rapid decrease in the mean arterial blood pressure (52 +/- 7 mmHg, mean +/- SE), lasting for 1-2 h. Hypotension was prevented or reverted by the platelet activating factor (PAF) antagonist SRI 63-675. The release of PAF from iron-loaded phagocytes may be due to magneto-orientational effects on membranes. This novel magnetic bioeffect can also be used for the study of PAF-mediated circulatory shock.

• Authors: K Mészáros
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 180 Issue 1 Pg. 315-22 (Oct 15 1991) ISSN: 0006-291X [Print] United States
• PMID: 1930228 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Platelet Activating Factor
• Quinolines
• SRI 63-675
• Iron

Topics

• Animals
• Blood Pressure (radiation effects)
• Electromagnetic Fields
• Hypotension (blood, physiopathology)
• Iron
• Male
• Microspheres
• Platelet Activating Factor (antagonists & inhibitors, physiology)
• Quinolines (pharmacology)
• Rats
• Rats, Inbred Strains