Abstract | PURPOSE: The influence of an irreversible inhibitor of constitutive NO synthase (L- NOArg; 1.0 mg/kg ip), a relatively selective inhibitor of inducible NO synthase (L-NIL; 1.0 mg/kg ip) and a relatively specific inhibitor of neuronal NO synthase (7-NI; 0.1 mg/kg ip), on antihyperalgesic action of selective antagonists of B2 and B1 receptors: D-Arg-[Hyp3,Thi5,D-Tic7,Oic8] bradykinin ( HOE 140; 70 nmol/kg ip) or des Arg10 HOE 140 (70 nmol/kg ip) respectively, in model of diabetic ( streptozotocin-induced) and toxic ( vincristine-induced) neuropathy was investigated. METHODS: The changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitto. RESULTS: CONCLUSIONS:
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Authors | Magdalena Bujalska, Helena Makulska-Nowak |
Journal | Neuro endocrinology letters
(Neuro Endocrinol Lett)
Vol. 30
Issue 1
Pg. 144-52
(Mar 2009)
ISSN: 0172-780X [Print] Sweden |
PMID | 19300402
(Publication Type: Journal Article)
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Chemical References |
- Bradykinin Receptor Antagonists
- Enzyme Inhibitors
- Hypoglycemic Agents
- Indazoles
- N(6)-(1-iminoethyl)lysine
- Receptors, Bradykinin
- Tetrahydroisoquinolines
- bradykinin, Hyp(3)-Thi(5)-Tic(7)-Oic(8)-desArg(9)-
- Nitroarginine
- Vincristine
- Streptozocin
- icatibant
- Nitric Oxide Synthase
- Lysine
- Bradykinin
- 7-nitroindazole
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Topics |
- Animals
- Bradykinin
(administration & dosage, analogs & derivatives, therapeutic use)
- Bradykinin Receptor Antagonists
- Diabetes Mellitus, Experimental
(chemically induced, complications, drug therapy)
- Diabetic Neuropathies
(chemically induced, drug therapy)
- Drug Evaluation, Preclinical
- Enzyme Inhibitors
(administration & dosage, therapeutic use)
- Hyperalgesia
(chemically induced, drug therapy, etiology)
- Hypoglycemic Agents
(administration & dosage, therapeutic use)
- Indazoles
(administration & dosage, therapeutic use)
- Lysine
(administration & dosage, analogs & derivatives, therapeutic use)
- Male
- Nitric Oxide Synthase
(antagonists & inhibitors)
- Nitroarginine
(administration & dosage, therapeutic use)
- Pain Measurement
- Rats
- Rats, Wistar
- Receptors, Bradykinin
(physiology)
- Streptozocin
- Tetrahydroisoquinolines
(administration & dosage, therapeutic use)
- Vincristine
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