Abstract | BACKGROUND: METHODS: Patients eligible for this study had cervical or ovarian cancer treated with chemotherapy; a course of the regimen consisted of 60 mg/m(2) of irinotecan on days 1, 8 and 15, and 60 mg/m(2) of cisplatin on day 1 every 4 weeks. UGT1A1 polymorphisms and toxicities were analyzed. RESULTS: From March 2007 to December 2007, 30 Japanese patients were enrolled; 24 ovarian carcinoma patients and 6 cervical cancer patients. The following genotypes of UGT1A1 were found: wild type in 17 patients (57%), *28 in 4 patients (13%), *6 in 8 patients (27%), *28*6 in 1 case (3%) and no case of *27 (0%). Grade 3/4 neutropenia, thrombocytopenia and diarrhea were significantly more frequent in *6 patients compared with wild-type patients. Also, in *6 patients irinotecan administration on days 8 or 15 was significantly more often omitted due to toxicities. In patients with *28 or *28*6, side effects were similar to those in patients with *6. CONCLUSION:
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Authors | Masashi Takano, Masafumi Kato, Tomoyuki Yoshikawa, Naoki Sasaki, Junko Hirata, Kenichi Furuya, Michiko Takahashi, Harushige Yokota, Nao Kino, Koji Horie, Tomoko Goto, Keiichi Fujiwara, Kenji Ishii, Yoshihiro Kikuchi, Tsunekazu Kita |
Journal | Oncology
(Oncology)
Vol. 76
Issue 5
Pg. 315-21
( 2009)
ISSN: 1423-0232 [Electronic] Switzerland |
PMID | 19299905
(Publication Type: Journal Article, Multicenter Study)
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Copyright | Copyright 2009 S. Karger AG, Basel. |
Chemical References |
- Irinotecan
- UGT1A1 enzyme
- Glucuronosyltransferase
- Cisplatin
- Camptothecin
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Camptothecin
(administration & dosage, analogs & derivatives)
- Cisplatin
(administration & dosage)
- Female
- Genotype
- Glucuronosyltransferase
(genetics)
- Humans
- Irinotecan
- Maximum Tolerated Dose
- Middle Aged
- Neoplasm Staging
- Ovarian Neoplasms
(drug therapy, genetics, pathology)
- Polymorphism, Genetic
- Prognosis
- Prospective Studies
- Risk Factors
- Treatment Outcome
- Uterine Cervical Neoplasms
(drug therapy, genetics, pathology)
- Young Adult
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