Abstract | INTRODUCTION: METHODS: RESULTS:
Hyperbaric oxygen therapy has been shown to ameliorate brain injury in a variety of animal models including focal cerebral ischemia, global cerebral ischemia, neonatal hypoxia- ischemia and subarachnoid hemorrhage. Small human trials of hyperbaric oxygen therapy in focal ischemia have not shown benefit, although one trial of hyperbaric oxygen therapy before cardiopulmonary bypass demonstrated improved neuropsychological and inflammatory outcomes with hyperbaric oxygen therapy. Hyperbaric oxygen therapy is associated with improved cerebral oxygenation, reduced blood-brain barrier breakdown, decreased inflammation, reduced cerebral edema, decreased intracranial pressure, reduced oxidative burden, reduced metabolic derangement, decreased apoptotic cell death and increased neural regeneration. CONCLUSION:
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Authors | Gerald A Matchett, Robert D Martin, John H Zhang |
Journal | Neurological research
(Neurol Res)
Vol. 31
Issue 2
Pg. 114-21
(Mar 2009)
ISSN: 0161-6412 [Print] England |
PMID | 19298750
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Topics |
- Animals
- Brain Ischemia
(therapy)
- Disease Models, Animal
- Humans
- Hyperbaric Oxygenation
(instrumentation, methods)
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