Lost in transcription--inhibition of RNA polymerase.

Abstract

Form and function: The natural product myxopyronin A provides the key to understanding the inhibition of bacterial RNA polymerase and should spark new ideas for the design of new antibiotics against tuberculosis and other infectious diseases.

• Authors: Dieter Haebich, Franz von Nussbaum
• Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 48 Issue 19 Pg. 3397-400 ( 2009) ISSN: 1521-3773 [Electronic] Germany
• PMID: 19294713 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antitubercular
• Enzyme Inhibitors
• Lactones
• myxopyronin A
• DNA-Directed RNA Polymerases

Topics

• Antibiotics, Antitubercular (chemistry, pharmacology)
• DNA-Directed RNA Polymerases (antagonists & inhibitors)
• Drug Design
• Enzyme Inhibitors (chemistry, pharmacology)
• Lactones (chemistry, pharmacology)
• Mycobacterium tuberculosis (drug effects, enzymology, genetics)
• Transcription, Genetic (drug effects)