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In vitro and in vivo studies of ME1228, a new parenteral cephalosporin with potent activity against Pseudomonas aeruginosa.

Abstract
The therapeutic effect of ME1228, a new parenteral cephalosporin, was compared with that of broad-spectrum cephems in normal and neutropenic mice infected with various species of bacteria. The results showed that ME1228 was more active than were the other cephems against infections with various pathogens.
AuthorsS Miyazaki, Y Miyazaki, A Tsuji, M Nishida, S Goto
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 35 Issue 6 Pg. 1245-6 (Jun 1991) ISSN: 0066-4804 [Print] United States
PMID1929274 (Publication Type: Journal Article)
Chemical References
  • Cephalosporins
  • ME 1228
Topics
  • Animals
  • Bacterial Infections (microbiology, prevention & control)
  • Cephalosporins (pharmacology)
  • Drug Evaluation, Preclinical
  • Humans
  • Male
  • Mice
  • Mice, Inbred ICR
  • Microbial Sensitivity Tests
  • Pseudomonas aeruginosa (drug effects)

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