Efficacy of different beta-lactams against an extended-spectrum beta-lactamase-producing Klebsiella pneumoniae strain in the rat intra-abdominal abscess model.

Abstract	Although standard-inoculum MICs were within the susceptible range for all compounds, cefoperazone, cefotaxime, and cefpirome were significantly less effective than imipenem or the combination of cefoperazone and sulbactam in the treatment of rat intra-abdominal abscesses due to an extended-spectrum beta-lactamase-producing strain of Klebsiella pneumoniae.
Authors	L B Rice, J D Yao, K Klimm, G M Eliopoulos, R C Moellering Jr
Journal	Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 35 Issue 6 Pg. 1243-4 (Jun 1991) ISSN: 0066-4804 [Print] United States
PMID	1929273 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Bacterial Agents beta-Lactams beta-Lactamases
Topics	Abdomen Abscess (drug therapy) Animals Anti-Bacterial Agents (pharmacology, therapeutic use) Klebsiella pneumoniae (drug effects, enzymology) Microbial Sensitivity Tests Rats beta-Lactamases (metabolism) beta-Lactams

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