Abstract | OBJECTIVE: METHODS: We collected maternal serum and partial placental tissues from 46 cases of preterm labor(21 cases of infectious proup with chorioamnionitis, 25 cases of noninfectious group without chorioamnionitis), while obtained maternal serum of 50 cases and placental tissues of 20 cases of term labor in contemporary period. TNF-alpha mRNA in placental tissue was tested by RT-PCR, Maternal serum level of TNF-alpha was measured by ELISA. Based on the genotype results of preliminary studies on TNF-alpha promoter -308 site, we analyzed the difference of placental TNF-alpha mRNA, maternal serum levels of TNF-alpha in different genotypes, and the relationship of different genotypes to chorioamnionitis. RESULTS: CONCLUSION:
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Authors | Jie Pu, Wei-Yue Zeng |
Journal | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
(Sichuan Da Xue Xue Bao Yi Xue Ban)
Vol. 40
Issue 1
Pg. 77-80
(Jan 2009)
ISSN: 1672-173X [Print] China |
PMID | 19292050
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- RNA, Messenger
- Tumor Necrosis Factor-alpha
|
Topics |
- Adult
- Female
- Humans
- Obstetric Labor, Premature
(genetics)
- Placenta
(metabolism)
- Polymorphism, Genetic
- Pregnancy
(blood)
- Promoter Regions, Genetic
(genetics)
- RNA, Messenger
(genetics, metabolism)
- Tumor Necrosis Factor-alpha
(blood, genetics, metabolism)
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