Neutralizing antibody against severe acute respiratory syndrome (SARS)-coronavirus spike is highly effective for the protection of mice in the murine SARS model.

Abstract	We evaluated the efficacy of three SARS vaccine candidates in a murine SARS model utilizing low-virulence Pp and SARS-CoV coinfection. Vaccinated mice were protected from severe respiratory disease in parallel with a low virus titer in the lungs and a high neutralizing antibody titer in the plasma. Importantly, the administration of spike protein-specific neutralizing monoclonal antibody protected mice from the disease, indicating that the neutralization is sufficient for protection. Moreover, a high level of IL-6 and MCP-1 production, but not other 18 cytokines tested, on days 2 and 3 after SARS-CoV infection was closely linked to the virus replication and disease severity, suggesting the importance of these cytokines in the lung pathogenicity of SARS-CoV infection.
Authors	Koji Ishii, Hideki Hasegawa, Noriyo Nagata, Yasushi Ami, Shuetsu Fukushi, Fumihiro Taguchi, Yasuko Tsunetsugu-Yokota
Journal	Microbiology and immunology (Microbiol Immunol) Vol. 53 Issue 2 Pg. 75-82 (Feb 2009) ISSN: 0385-5600 [Print] Australia
PMID	19291090 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antibodies, Monoclonal Antibodies, Viral Chemokine CCL2 Interleukin-6 Membrane Glycoproteins Spike Glycoprotein, Coronavirus Vaccines, Inactivated Viral Envelope Proteins Viral Vaccines spike glycoprotein, SARS-CoV
Topics	Animals Antibodies, Monoclonal (immunology) Antibodies, Viral (immunology) Body Weight Chemokine CCL2 (analysis) Disease Models, Animal Interleukin-6 (analysis) Membrane Glycoproteins (immunology) Mice Mice, Inbred BALB C Neutralization Tests Severe acute respiratory syndrome-related coronavirus (immunology, physiology) Severe Acute Respiratory Syndrome (immunology, prevention & control, virology) Spike Glycoprotein, Coronavirus Vaccines, Inactivated Viral Envelope Proteins (immunology) Viral Vaccines (immunology) Virus Replication

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