Abstract | OBJECTIVE: METHODS: We searched the National Library of Medicine's PubMed database for all relevant articles published on the topic through November 2006. Inclusion criteria included double-blind, randomized controlled trials and use of a visual analog scale to measure pain on infiltration of local anesthetic buffered with sodium bicarbonate compared with that of unbuffered local anesthetic. Meta-analysis was performed using the Review Manager 4.2.7 (The Cochrane Collaboration, 2004). A random-effects model was used. RESULTS: Our search resulted in 86 abstracts, of which 12 articles met all inclusion criteria. Overall, there were 609 observations for buffered local anesthetic and 615 for unbuffered local anesthetic. Use of buffered local anesthetic resulted in a statistically lower weighted mean difference in visual analog scale of -1.17 (95% confidence interval, -1.68 to -0.67) compared with unbuffered local anesthetic. CONCLUSIONS: Our systematic review suggests that the use of buffered local anesthetics seems to be associated with a statistical decrease in pain of infiltration when compared with unbuffered local anesthetic.
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Authors | Marie N Hanna, Amir Elhassan, Patricia M Veloso, Maggie Lesley, Jon Lissauer, Jeffrey M Richman, Christopher L Wu |
Journal | Regional anesthesia and pain medicine
(Reg Anesth Pain Med)
2009 Mar-Apr
Vol. 34
Issue 2
Pg. 122-5
ISSN: 1532-8651 [Electronic] England |
PMID | 19282711
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Chemical References |
- Anesthetics, Local
- Bicarbonates
- Buffers
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Topics |
- Anesthetics, Local
(administration & dosage, adverse effects, chemistry)
- Bicarbonates
(administration & dosage)
- Buffers
- Female
- Humans
- Hydrogen-Ion Concentration
- Injections, Intradermal
- Male
- Pain
(chemically induced, prevention & control)
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