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A patient with acute myeloid leukemia who developed fatal pneumonia caused by carbapenem-resistant Bacillus cereus.

Abstract
Bacillus cereus is known as a serious bacterial pathogen in neutropenic patients. B. cereus is often resistant to beta-lactams, including penicillins and cephalosporins. We report a case of fatal pneumonia caused by B. cereus in a patient with newly diagnosed acute myeloid leukemia (AML) during remission induction therapy. Cefepime was started for febrile neutropenia (FN) initially and was switched to panipem/betamipron, when fulminant pneumonia supervened. The isolated strain was resistant not only to cefepime but also to panipenem/betamipron. This is the first report of fulminant infection caused by carbapenem-resistant B. cereus in a neutropenic patient. B. cereus should be kept in mind as a target of empirical treatment when neutropenic patients develop pneumonia.
AuthorsHiroo Katsuya, Tohru Takata, Takahiko Ishikawa, Hidenori Sasaki, Kenji Ishitsuka, Yasushi Takamatsu, Kazuo Tamura
JournalJournal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (J Infect Chemother) Vol. 15 Issue 1 Pg. 39-41 (Feb 2009) ISSN: 1341-321X [Print] Netherlands
PMID19280299 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Carbapenems
Topics
  • Anti-Bacterial Agents (pharmacology, therapeutic use)
  • Antineoplastic Agents (adverse effects, therapeutic use)
  • Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
  • Bacillaceae Infections (complications, drug therapy, microbiology)
  • Bacillus cereus (drug effects, isolation & purification)
  • Carbapenems (pharmacology, therapeutic use)
  • Fatal Outcome
  • Humans
  • Immunocompromised Host
  • Leukemia, Myeloid, Acute (complications, diagnosis, drug therapy)
  • Lung (diagnostic imaging)
  • Male
  • Middle Aged
  • Neutropenia
  • Pneumonia, Bacterial (complications, drug therapy, microbiology)
  • Remission Induction
  • Tomography, X-Ray Computed
  • beta-Lactam Resistance

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