[Indications of anakinra].

Abstract

The efficacy of anakinra on both RA-related symptoms and structural damage has been demonstrated in several randomized controlled trials. However, its interest seems limited with regards to other biologic agents. Anakinra seems promising in the treatment of childhood or adult onset Still disease, after the failure of both high dose steroids and methotrexate. The efficacy of anakinra is dramatic in several hereditary auto-inflammatory syndromes. Anakinra could be an interesting drug for the treatment of neutrophilic dermatosis or relapsing chondritis, refractory to conventional agents. Injection site reactions and infections are the 2 main anakinra-related side effects.

• Authors: Karine Chauffier, Jonathan London, Constance Beaudouin, Bruno Fautrel
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 38 Issue 5 Pg. 799-807 (May 2009) ISSN: 2213-0276 [Electronic] France
• Vernacular Title: Indications de l'anakinra.
• PMID: 19278814 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antirheumatic Agents
• Interleukin 1 Receptor Antagonist Protein

Topics

• Antirheumatic Agents (pharmacology, therapeutic use)
• Arthritis, Rheumatoid (drug therapy)
• Drug Therapy, Combination
• Gout (drug therapy)
• Humans
• Interleukin 1 Receptor Antagonist Protein (pharmacology, therapeutic use)
• Polychondritis, Relapsing (drug therapy)
• Sweet Syndrome (drug therapy)