Direct and short-time uptake of [70]fullerene into the cell membrane using an exchange reaction from a [70]fullerene-gamma-cyclodextrin complex and the resulting photodynamic activity.

Abstract

[70]Fullerene (C70) was directly incorporated into the cell membrane using an exchange reaction from a C70-gamma-cyclodextrin (gamma-CDx) complex within 10 min and the incorporated C70 acted as a photodynamic sensitiser for a cancer cell.

• Authors: Atsushi Ikeda, Masashi Matsumoto, Motofusa Akiyama, Jun-ichi Kikuchi, Takuya Ogawa, Tatsuo Takeya
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Issue 12 Pg. 1547-9 (Mar 28 2009) ISSN: 1359-7345 [Print] England
• PMID: 19277385 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fullerenes
• Macromolecular Substances
• Photosensitizing Agents
• gamma-Cyclodextrins
• fullerene C70
• gamma-cyclodextrin

Topics

• Absorption
• Cell Membrane (physiology)
• Fullerenes (chemistry, pharmacokinetics)
• HeLa Cells
• Humans
• Macromolecular Substances (chemistry)
• Models, Biological
• Photosensitizing Agents (chemistry)
• Spectrophotometry
• gamma-Cyclodextrins (chemistry)