Parasitic lung infections.

Global climate change and population explosion leading to changes in natural ecosystem and travel across the continents have resulted in an increase in the transmission of parasites to human beings. This review focuses on recent advancements in parasitic lung infections.
Invasive parasitic diseases including lung infections are increasingly being reported in patients with immunodeficiency syndromes. A recombinant kinesin-related antigen of Leishmania donovani has been validated with ELISA using urine samples for the diagnosis of visceral leishmaniasis. Pyruvate kinase deficiency has been shown to provide protection against Plasmodium falciparum infection. Intravenous artesunate is an alternative drug for the treatment of severe malaria. The best way to protect from malaria is the use of long-lasting insecticide-treated bednets. Biennial treatment with praziquantel has been found to be cost-effective treatment for control of infection with Schistosoma haematobium. Pulmonary paragonimiasis can be diagnosed by fine needle aspiration biopsy of pulmonary nodules. Strongyloides stercoralis hyperinfection can mimic accelerated idiopathic pulmonary fibrosis. Migratory nodular shadows with halos are important chest computed tomographic findings in human toxocariasis.
Patients with immunodeficiency syndromes (HIV infection, organ transplantation and immunosuppressive drugs, including corticosteroids) should be evaluated for early detection of parasitic lung infections.
AuthorsVannan Kandi Vijayan
JournalCurrent opinion in pulmonary medicine (Curr Opin Pulm Med) Vol. 15 Issue 3 Pg. 274-82 (May 2009) ISSN: 1531-6971 [Electronic] United States
PMID19276810 (Publication Type: Journal Article, Review)
Chemical References
  • Antiparasitic Agents
  • Immunosuppressive Agents
  • Antiparasitic Agents (therapeutic use)
  • Greenhouse Effect
  • Humans
  • Immunocompromised Host
  • Immunosuppressive Agents (adverse effects)
  • Lung Diseases, Parasitic (diagnosis, drug therapy, epidemiology)
  • Opportunistic Infections (diagnosis, epidemiology, parasitology)
  • Prevalence
  • Risk Factors

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