Abstract | INTRODUCTION: SETTING: RESULTS: CONCLUSION: Patients on fluouropyrimidine drugs with new neurological symptoms should be investigated with brain MRI scan and the drug should be withdrawn until symptoms resolve. Dihydropyrimidine dehydrogenase deficiency should be excluded and ideally an alternative chemotherapy regime sought. We would encourage reporting of such incidences to gain a clearer picture of the incidence and optimal management.
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Authors | Karen Tipples, Rajeev B Kolluri, Sherif Raouf |
Journal | Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
(J Oncol Pharm Pract)
Vol. 15
Issue 4
Pg. 237-9
(Dec 2009)
ISSN: 1477-092X [Electronic] England |
PMID | 19276137
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibiotics, Antineoplastic
- Antimetabolites, Antineoplastic
- Antineoplastic Agents
- Deoxycytidine
- Epirubicin
- Capecitabine
- Cisplatin
- Fluorouracil
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Topics |
- Adenocarcinoma
(complications, drug therapy, pathology)
- Antibiotics, Antineoplastic
(administration & dosage)
- Antimetabolites, Antineoplastic
(administration & dosage, adverse effects, therapeutic use)
- Antineoplastic Agents
(administration & dosage)
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Brain Diseases
(cerebrospinal fluid, chemically induced, psychology)
- Capecitabine
- Cisplatin
(administration & dosage)
- Deoxycytidine
(administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
- Epirubicin
(administration & dosage)
- Esophageal Neoplasms
(complications, drug therapy, pathology)
- Fluorouracil
(administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
- Humans
- Liver Neoplasms
(drug therapy, secondary)
- Male
- Middle Aged
- Neurotoxicity Syndromes
(cerebrospinal fluid, etiology, psychology)
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