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HIV-1 Vpr: regulator of viral survival.

Abstract
The HIV-1 Vpr protein is a viral accessory protein that plays a number of important roles during HIV infection. The activities of Vpr are numerous and include the induction of apoptosis, the modulation of cell cycle arrest, as well as control of viral transcription. Study of HIV clones lacking Vpr in vitro and analysis of HIV variants isolated from long-term nonprogressors in vivo highlight the importance of Vpr for viral replication as well as immune suppression and cell death. Vpr may therefore be considered among the most important accessory proteins encoded by HIV.
AuthorsKhanh P Thieu, Matthew P Morrow, Devon J Shedlock, Kimberly A Schoenly, Karthikbabu Mallilankaraman, Andrew Y Choo, Paolo Fagone, David B Weiner, Karuppiah Muthumani
JournalCurrent HIV research (Curr HIV Res) Vol. 7 Issue 2 Pg. 153-62 (Mar 2009) ISSN: 1873-4251 [Electronic] Netherlands
PMID19275584 (Publication Type: Journal Article, Review)
Chemical References
  • vpr Gene Products, Human Immunodeficiency Virus
  • vpr protein, Human immunodeficiency virus 1
Topics
  • HIV-1 (immunology, physiology)
  • Humans
  • Immune Tolerance
  • Virus Replication
  • vpr Gene Products, Human Immunodeficiency Virus (physiology)

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