[Fluoroquinolones: antimicrobial activity and chemotherapeutic efficacy with respect to various pathogens in highly dangerous diseases].

Abstract

Comparative in vitro and in vivo efficacy of new fluoroquinolones with respect to pathogens of tularemia, glanders, melioidosis and anthrax was estimated. It was shown that the strains of the tularemia, glanders, melioidosis and anthrax pathogens were in vitro highly susceptible to the new agents. The experiments on laboratory animals demonstrated that pefloxacin and sparfloxacin had extremely broad spectra and were of special value in emergency prophylaxis of tularemia, glanders, melioidosis and anthrax.

• Authors: T A Bondareva, V B Kalininskiĭ, I V Borisevich, V P Bondarev, V V Kozhukhov, M Iu Amosov, G V Baramzina, O O Fomenkov, F V Krinitsyn
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 52 Issue 11-12 Pg. 21-4 ( 2007) ISSN: 0235-2990 [Print] Russia (Federation)
• PMID: 19275053 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Fluoroquinolones

Topics

• Animals
• Anthrax (drug therapy, microbiology)
• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Bacillus anthracis (drug effects)
• Burkholderia pseudomallei (drug effects)
• Cricetinae
• Fluoroquinolones (pharmacology, therapeutic use)
• Francisella tularensis (drug effects)
• Glanders (drug therapy, microbiology)
• Guinea Pigs
• Melioidosis (drug therapy, microbiology)
• Mesocricetus
• Tularemia (drug therapy, microbiology)