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CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases.

Abstract
Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune adjuvants, accelerating and boosting antigen-specific immune responses. CpG motifs promote the induction of Th1 and pro-inflammatory cytokines and support the maturation/activation of professional antigen presenting cells (particularly plasmacytoid dendritic cells). These effects are optimized by maintaining close physical contact between the CpG ODN and the immunogen. Co-administering CpG ODN with a variety of vaccines has improved the resultant humoral and/or cellular immune responses, culminating in enhanced protective immunity in rodent and primate challenge models. Ongoing clinical studies indicate that CpG ODN are safe and well-tolerated when administered as adjuvants to humans, and that they can support increased vaccine-specific immune responses.
AuthorsDennis M Klinman, Sven Klaschik, Takashi Sato, Debbie Tross
JournalAdvanced drug delivery reviews (Adv Drug Deliv Rev) Vol. 61 Issue 3 Pg. 248-55 (Mar 28 2009) ISSN: 1872-8294 [Electronic] Netherlands
PMID19272313 (Publication Type: Journal Article, Review)
Chemical References
  • Adjuvants, Immunologic
  • Bacterial Vaccines
  • CPG-oligonucleotide
  • Cytokines
  • Oligodeoxyribonucleotides
  • Viral Vaccines
Topics
  • Adjuvants, Immunologic (administration & dosage, adverse effects, therapeutic use)
  • Animals
  • Antibody Formation
  • Bacterial Vaccines (administration & dosage, immunology)
  • Communicable Disease Control
  • Communicable Diseases (immunology)
  • CpG Islands
  • Cytokines (biosynthesis, immunology)
  • Humans
  • Immunity, Mucosal
  • Oligodeoxyribonucleotides (administration & dosage, adverse effects, therapeutic use)
  • Viral Vaccines (administration & dosage, immunology)

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