Abstract | OBJECTIVES: METHODS: RESULTS:
Coronary artery disease patients had higher Lp(a) levels than controls (25.78 +/- 25.09 mg/dl versus 14.57 +/- 11.81 mg/dl, p=0.0030). Patients without stenosis (10.97 +/- 8.06 mg/dl) and one vessel involvement (19.67 +/- 17.33 mg/dl) had significantly lower levels of Lp(a) compared to double (31.88 +/- 32.17 mg/dl) and triple (29.70 +/- 28.12 mg/dl) vessel disease. Lipoprotein(a) levels correlated significantly with coronary vessel score (r=0.234, p=0.033) and Gensini score (r=0.256, p=0.02). Smoking (odds ratio [OR]: 1.86; 95% confidence interval [CI]: 1.020-2.510; p=0.04), TG levels (OR: 2.04; 95% CI: 1.251-4.932; p=0.03) and Lp(a) levels (OR: 1.56; 95% CI: 1.033-3.687; p=0.025) significantly predicted CAD severity. High risk levels of Lp(a) >/= 30 mg/dL were present in 66.7% of CAD patients. CONCLUSION:
Lipoprotein(a) levels are significantly higher in Saudi patients with CAD compared to healthy individuals, and are associated with more severe and diffuse blockage of the coronary vessels.
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Authors | Syed S Habib, Abdelgalil M Abdel-Gader, Mohammad I Kurdi, Zohair Al-Aseri, Mona M Soliman |
Journal | Saudi medical journal
(Saudi Med J)
Vol. 30
Issue 3
Pg. 346-52
(Mar 2009)
ISSN: 0379-5284 [Print] Saudi Arabia |
PMID | 19271061
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Cholesterol, HDL
- Cholesterol, LDL
- Lipoprotein(a)
- Triglycerides
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Topics |
- Analysis of Variance
- Biomarkers
(blood)
- Case-Control Studies
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Coronary Angiography
- Coronary Disease
(blood, diagnostic imaging, epidemiology)
- Cross-Sectional Studies
- Female
- Humans
- Lipoprotein(a)
(blood)
- Logistic Models
- Male
- Middle Aged
- Saudi Arabia
(epidemiology)
- Severity of Illness Index
- Statistics, Nonparametric
- Triglycerides
(blood)
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