Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features.

Abstract

We tested four genes [phenylalanine hydroxylase (PAH), the serotonin transporter (SLC6A4), monoamine oxidase B (MAOB), and the gamma-aminobutyric acid A receptor beta-3 subunit (GABRB3)] for their impact on five schizophrenia symptom factors: delusions, hallucinations, mania, depression, and negative symptoms. In a 90 family subset of the Irish Study of High Density Schizophrenia Families, the PAH 232 bp microsatellite allele demonstrated significant association with the delusions factor using both QTDT (F=8.0, p=.031) and QPDTPHASE (chi-square=12.54, p=.028). Also, a significant association between the GABRB3 191 bp allele and the hallucinations factor was detected using QPDTPHASE (chi-square=15.51, p=.030), but not QTDT (chi-square=2.07, p=.560).

• Authors: Sarah E Bergen, Ayman H Fanous, Dermot Walsh, F Anthony O'Neill, Kenneth S Kendler
• Journal: Schizophrenia research (Schizophr Res) Vol. 109 Issue 1-3 Pg. 94-7 (Apr 2009) ISSN: 0920-9964 [Print] Netherlands
• PMID: 19268543 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Genetic Markers
• Membrane Transport Proteins
• Receptors, GABA
• SLC6A4 protein, human
• Serotonin Plasma Membrane Transport Proteins
• Phenylalanine Hydroxylase
• Monoamine Oxidase

Topics

• Delusions (genetics)
• Family
• Gene Frequency
• Genetic Markers (genetics)
• Genetic Predisposition to Disease (genetics)
• Genetic Variation
• Genome-Wide Association Study
• Genotype
• Hallucinations (genetics)
• Humans
• Membrane Transport Proteins (genetics)
• Monoamine Oxidase (genetics)
• Phenylalanine Hydroxylase (genetics)
• Polymorphism, Genetic
• Polymorphism, Single Nucleotide
• Psychotic Disorders (diagnosis, genetics, psychology)
• Receptors, GABA (genetics)
• Schizophrenia (diagnosis, genetics)
• Serotonin Plasma Membrane Transport Proteins (genetics)