Isariotins E and F, spirocyclic and bicyclic hemiacetals from the entomopathogenic fungus Isaria tenuipes BCC 12625.

Abstract

New spirocyclic and bicyclic hemiacetals, isariotins E (1) and F (2), together with TK-57-164A (3) were isolated from the entomopathogenic fungus Isaria tenuipes BCC 12625. The absolute configuration of 3 was addressed by application of the modified Mosher's method. Isariotin F (2) exhibited activity against the malaria parasite Plasmodium falciparum K1 with an IC(50) value of 5.1 microM and cytotoxic activities against cancer cell lines (KB, BC, and NCI-H187) and nonmalignant (Vero) cells with respective IC(50) values of 15.8, 2.4, 1.6, and 2.9 microM.

• Authors: Taridaporn Bunyapaiboonsri, Seangaroon Yoiprommarat, Kamolphan Intereya, Pranee Rachtawee, Nigel L Hywel-Jones, Masahiko Isaka
• Journal: Journal of natural products (J Nat Prod) Vol. 72 Issue 4 Pg. 756-9 (Apr 2009) ISSN: 1520-6025 [Electronic] United States
• PMID: 19265430 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antimalarials
• Antineoplastic Agents
• Antitubercular Agents
• Bridged Bicyclo Compounds, Heterocyclic
• Epoxy Compounds
• Heterocyclic Compounds, Bridged-Ring
• Spiro Compounds
• TK-57-164A
• isariotin E
• isariotin F

Topics

• Animals
• Antimalarials (chemistry, isolation & purification, pharmacology)
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Antitubercular Agents (chemistry, isolation & purification, pharmacology)
• Bridged Bicyclo Compounds, Heterocyclic (chemistry, isolation & purification, pharmacology)
• Candida albicans (drug effects)
• Chlorocebus aethiops
• Drug Screening Assays, Antitumor
• Epoxy Compounds (chemistry, isolation & purification)
• Heterocyclic Compounds, Bridged-Ring (chemistry, isolation & purification)
• Humans
• Hypocreales (chemistry)
• Inhibitory Concentration 50
• Molecular Structure
• Mycobacterium tuberculosis (drug effects)
• Parasitic Sensitivity Tests
• Plasmodium falciparum (drug effects)
• Spiro Compounds (chemistry, isolation & purification, pharmacology)
• Thailand
• Vero Cells