[Cutaneous non-Hodgkin lymphoma of the leg occurring 11 years after renal transplantation].

Abstract

A 54-year-old woman was diagnosed as having polycystic kidney in 1990. Renal transplantation was performed in 1995. She received immunosuppressive therapy postoperatively. Skin lesion was recognized on the left leg in April 2002 and skin biopsy demonstrated diffuse large B cell lymphoma in March 2006. EBV-LMP, EBNA-2 and EBER were positive and she was diagnosed as having EBV-related posttransplant lymphoproliferative disease (PTLD). Radiation therapy and rituximab therapy were administered. The skin ulcer worsened and she was referred to our hospital. We reduced the dose of immunosuppressive drug and performed debridement of the ulcer, which responded well to treatment. PTLD presenting with skin involvement rarely manifests as lesions, and such lesions develop slowly, when they occur. PTLD presenting with skin involvement after transplantation must be treated.

• Authors: Kyoko Kudo, Masao Sonoda, Keiji Sugimoto, Michiaki Koike
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 50 Issue 2 Pg. 107-9 (Feb 2009) ISSN: 0485-1439 [Print] Japan
• PMID: 19265304 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Immunosuppressive Agents

Topics

• Debridement
• Epstein-Barr Virus Infections (complications)
• Female
• Humans
• Immunosuppressive Agents (administration & dosage)
• Kidney Transplantation (adverse effects)
• Lymphoma, Large B-Cell, Diffuse (etiology, therapy)
• Lymphoproliferative Disorders (etiology, therapy)
• Middle Aged
• Polycystic Kidney Diseases (surgery)
• Skin Neoplasms (etiology, therapy)
• Time Factors